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KMID : 1161420190220020186
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Journal of Medicinal Food
2019 Volume.22 No. 2 p.186 ~ p.195
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Characterization of Soybean Germinated Embryo Extract as an Estrogen Receptor Subtype-Selective and Tissue-Specific Modulator
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Jeong Hye-Soo
Lee Ji-Min
Kim Soo-Lin
Park Su-Jeong
Yang Hwa-Sun
Ahn Byoung-Ha
Jang Chang-Young
Jeong Hyun-Cheol
Lee Sung-Jin
Kim Sun-Lim
Seo Woo-Duck
Sohn Jo-Hann
Chang Min-Sun
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Abstract
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Phytoestrogens possess beneficial effects in the management of menopausal symptoms with few side effects. Soybeans are major natural sources of isoflavones, with high estrogen receptor (ER)-β selectivity. The objective of this study therefore was to develop a solvent-mediated extraction method for soybean germinated embryos (SGEs) and to investigate the biological activities of the extract. Ethanolic extraction yielded the SGE extract (SGEE), which had a unique composition of biologically active aglycones and soyasaponins. SGEE showed a proliferative effect in MCF7 cells and ERβ-selective transcriptional activities in human embryonic kidney cells. In addition, oral administration of SGEE to ovariectomized rats resulted in the induction of ERβ and estrogen-responsive genes in the uterus and a decrease in tail skin temperature and uterus weight. Our data suggest that germination and ethanolic extraction are effective measures for producing isoflavone-rich food supplements, which may be useful as alternative menopausal hormone therapy.
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KEYWORD
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estrogen receptor modulator, germinated soy embryo, isoflavones, menopausal hormone therapy, soyasaponins
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